2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HMG-CoA Reductase (HMGCR)
  5. HMG-CoA Reductase (HMGCR) Control

HMG-CoA Reductase (HMGCR) Control

HMG-CoA Reductase (HMGCR) Controls (7):

Cat. No. Product Name Effect Purity
  • HY-135383
    (3S,5S)-Pitavastatin calcium
    		Control 99.94%
    (3S,5S)-Pitavastatin cacium is the 3-epimer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
  • HY-N11637A
    (Z)-Ganoderenic acid K
    		Control
    (Z)-Ganoderenic acid K is a triterpene acid that can be isolated from the basidiocarp of Ganoderma lucidum. Ganoderenic acid K (HY-N11637), the isomer of (Z)-Ganoderenic acid K, is a HMG-CoA reductase (HMGCR) inhibitor with an IC50 of 16.5 μM.
  • HY-137213
    Fluvastatin lactone
    		Control
    Fluvastatin lactone, a lactone form of Fluvastatin (HY-14664), induces myotoxicity in human skeletal muscle cells.
  • HY-Z10518
    ((3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II)
    		Control
    ((3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II) is an impurity found in bulk preparations of the HMG-CoA reductase inhibitor Rosuvastatin (HY-17504A).
  • HY-135383A
    (3S,5R)-Pitavastatin calcium
    		Control
    (3S,5R)-Pitavastatin cacium is the enantiomer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
  • HY-135383B
    (Z)-Pitavastatin calcium
    		Control
    (Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin calcium inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells.
  • HY-169818
    Keto lovastatin
    		Control
    Keto lovastatin is an impurity of Lovastatin (HY-N0504) with antibacterial activity. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.